Jan Willms

Jan Willms Medical Doctor University Hospital Zürich (USZ)

Dr. med. Jan Willms is a senior physician in the neurosurgical intensive care unit and leads several research projects for the support of clinical decision management through AI applications. He has extensive clinical experience in the recognition of various neuro-intensive care pathologies, such as Delayed Cerebral Ischemia (DCI) or Burst Suppression.

2026

Heart Rate Variability Integrated into a Longitudinal Multimodal Model to Predict Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage

Valerie C. Schütz, Jens M. Boss, Corinne Inauen, Stefan Y. Bögli, Tilman Beck, Emanuela Keller, Jan F. Willms

Bioengineering · 25 Jul 2026 · doi:10.3390/bioengineering13080857

Silent Validation of a Longitudinal Model for Predicting Delayed Cerebral Ischemia in Real Time after Subarachnoid Hemorrhage

Jan Willms, Jenny Schmid, Corinne Inauen, Stefan Yu Bögli, Nadine Bienefeld-Seall, Tilman Beck, Jens Boss, Emanuela Keller

NEJM AI · 22 Jan 2026 · doi:10.1056/AIoa2500749

2022

Functional NIRS to detect covert consciousness in neurocritical patients

Giulio Bicciato, Gagan Narula, Giovanna Brandi, Amanda Eisele, Sven Schulthess, Susanne Friedl, Jan Folkard Willms, Laura Westphal, Emanuela Keller

Clinical Neurophysiology · 01 Dec 2022 · doi:10.1016/J.CLINPH.2022.10.002

Blood Pressure Variability Indices for Outcome Prediction After Thrombectomy in Stroke by Using High-Resolution Data

Corinne Inauen, Jens M. Boss, Mira Katan, Andreas R. Luft, Zsolt Kulcsar, Jan F. Willms, Stefan Y. Bögli, Emanuela Keller

Neurocritical Care · 04 Nov 2022 · doi:10.1007/s12028-022-01519-x

Single-antiplatelet regimen in ruptured cerebral blood blister and dissecting aneurysms treated with flow-diverter stent reconstruction

Jawid Madjidyar, Emanuela Keller, Sebastian Winklhofer, Daniel Toth, Isabelle Barnaure, …, Patrick Thurner, Jorn Fierstra, Jan Folkard Willms, Luca Regli, Zsolt Kulcsar

Journal of NeuroInterventional Surgery · 03 Nov 2022 · doi:10.1136/JNIS-2022-019361

ICU Cockpit: a platform for collecting multimodal waveform data, AI-based computational disease modeling and real-time decision support in the intensive care unit

Jens Michael Boss, Gagan Narula, Christian Straessle, Jan Willms, Jan Azzati, …, Carl Muroi, David Jule Mack, Marko Seric, Daniel Baumann, Emanuela Keller

Journal of the American Medical Informatics Association · 14 Jul 2022 · doi:10.1093/jamia/ocac064

Spontaneous empyema and brain abscess in an intensive care population: clinical presentation, microbiology, and factors associated with outcome

Sabeth Dietler, Jan Willms, Giovanna Brandi, Sophie Wang, Astrid Burkerth, Emanuela Keller

Acta Neurochirurgica · 27 May 2022 · doi:10.1007/s00701-022-05241-7

Functional relationship of arterial blood pressure, central venous pressure and intracranial pressure in the early phase after subarachnoid hemorrhage

Gabriela Maissen, Gagan Narula, Christian Strässle, Jan Willms, Carl Muroi, Emanuela Keller

Technology and Health Care · 12 May 2022 · doi:10.3233/THC-212956

Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients

Sven Jarius, Florence Pache, Peter Körtvelyessy, Ilijas Jelčić, Mark Stettner, …, Hayrettin Tumani, Friedemann Paul, Martin Stangel, Klemens Ruprecht, Brigitte Wildemann

Journal of Neuroinflammation · 20 Jan 2022 · doi:10.1186/S12974-021-02339-0

Solving the Explainable AI Conundrum: How to Bridge the Gap Between Clinicians Needs and Developers Goal

Nadine Bienefeld, Rahel Lüthy, Dominique Brodbeck, Jens Boss, Jan Willms, Jan Azzati, Mirco Blaser, Emanuela Keller

[no publisher info] · 01 Jan 2022 · ppr:PPR581109

2021

Increase in Low-Frequency Oscillations in fNIRS as Cerebral Response to Auditory Stimulation with Familiar Music

Giulio Bicciato, Emanuela Keller, Martin Wolf, Giovanna Brandi, Sven Schulthess, Susanne Gabriele Friedl, Jan Folkard Willms, Gagan Narula

Brain Sciences · 29 Dec 2021 · doi:10.3390/BRAINSCI12010042

Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury

Kevin Akeret, Raphael M Buzzi, Christian A Schaer, Bart R Thomson, Florence Vallelian, …, Rok Humar, Luca Regli, Emanuela Keller, Michael Hugelshofer, Dominik J Schaer

Journal of Cerebral Blood Flow & Metabolism · 08 Jun 2021 · doi:10.1177/0271678X211020629

The effect of nimodipine on pulmonary function in artificially ventilated patients with aneurysmal subarachnoid hemorrhage

Justyna Lunkiewicz, Giovanna Brandi, Jan Willms, Christian Strässle, Gagan Narula, Emanuela Keller, Carl Muroi

Acta Neurochirurgica · 07 Apr 2021 · doi:10.1007/S00701-021-04837-9

2020

Large and Small Cerebral Vessel Involvement in Severe COVID-19: Detailed Clinical Workup of a Case Series.

Emanuela Keller, Giovanna Brandi, Sebastian Winklhofer, Lukas L Imbach, Daniel Kirschenbaum, …, Andreas Lutterotti, Christoph Stippich, Christoph Globas, Zsuzsanna Varga, Ilijas Jelcic

Stroke · 15 Oct 2020 · pmid:33054673

Central Nervous System Disorders in Severe SARS-CoV-2 Infection: detailed clinical work-up of eight case

Emanuela Keller, Giovanna Brandi, Sebastian Winklhofer, Lukas Imbach, Daniel Kirschenbaum, …, Adrian Waeckerlin, Irene Alma Abela, Andreas Lutterotti, Christoph Stippich, Ilijas Jelcic

[no publisher info] · 01 Jan 2020 · ppr:PPR171009

2018

Safety, Feasibility, and Efficiency of a New Cooling Device Using Intravenous Cold Infusions for Fever Control

J. F. Willms, O. Boss, E. Keller

Neurocritical Care · 10 Aug 2018 · doi:10.1007/s12028-018-0588-7

2016

Missed Anterior Inferior Cerebellar Artery Aneurysm Mimicking Vestibular Neuritis-Clues to Prevent Misdiagnosis.

Jan-Folkard Willms, Gerasimos Baltsavias, Jan-Karl Burkhardt, Silvia Ernst, Alexander A Tarnutzer

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 13 Oct 2016 · pmid:27746081

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